Fig. 1: EGFL7 correlates to EGFR inhibitors resistance in cancer. | Cell Death & Disease

Fig. 1: EGFL7 correlates to EGFR inhibitors resistance in cancer.

From: EGFL7 drives the evolution of resistance to EGFR inhibitors in lung cancer by activating NOTCH signaling

Fig. 1

A Volcano plot representing differential expressed genes between non-responders (NR) and responders (R) to EGFR inhibitors (data from TCGA database). B Volcano plot representing differential expressed genes between PC9OR cells and PC9 cells. Common genes in A and B are represented as red dots. C Heat map showing relative abundance of common differential expressed genes in A and B. D Expression of EGFL7 transcripts in PC9 cells (PC9parental), gefitinib-derived PC9 tolerant cells and WZ4002-derived PC9 tolerant cells upon vehicle, EGFR inhibitor gefitinib (GEF) or EGFR inhibitor WZ4002 (WZ) treatment (GSE75602). Data are shown as mean values of two replicates. p values are calculated by DEG package in R (see method). (ns, p > 0.05; ***p < 0.001).

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