Fig. 5: EGFL7 activates NOTCH signaling extracellularly. | Cell Death & Disease

Fig. 5: EGFL7 activates NOTCH signaling extracellularly.

From: EGFL7 drives the evolution of resistance to EGFR inhibitors in lung cancer by activating NOTCH signaling

Fig. 5

A Schematic of experimental workflow for cell competition assay to access the relative fitness in osimertinib (Osm) exposure. B FACS plot presenting cell number across different fluorescence intensity in the mixture of PC9 cells and EGFL7-knockdown PC9 cells (right panel) or control cells (PC9_ sh-NC, left panel). C Bar plot presenting the statistic results from B. D Boxplot presenting NOTCH signaling scores in low, medium and high mCherry expression PC9 subgroups with a 14-day osimertinib treatment (GSE150949, N = 26,990, see methods). FACS indicates fluorescent-activated cell sorting. p values are calculated by one-way ANNOVA with Tukey multiple comparisons (ns, p > 0.05; ***p < 0.001).

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