Fig. 8: A model for the transition from sensitive cells to persister cells during EGFR kinase inhibition. | Cell Death & Disease

Fig. 8: A model for the transition from sensitive cells to persister cells during EGFR kinase inhibition.

From: EGFL7 drives the evolution of resistance to EGFR inhibitors in lung cancer by activating NOTCH signaling

Fig. 8

The cartoon depicts dynamic process as EGFR kinase inhibition elongates. Phenotypically, cells first remain nearly normal then experience rapid number decline and finally a small fraction transform into persister cells. Accordingly, the activity of EGFL7/NOTCH signaling is low in the first stage, increasing during the decimation phase and maintain high since then, decelerating the decline of c-Myc and ultimately contributing to the formation persister cells. Knockdown of EGFL7 largely disturbs this process and results in a lower fraction of persister cells.

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