Fig. 4: G-1 and venetoclax synergistically improve the immune function of CD8+ T cells. | Cell Death & Disease

Fig. 4: G-1 and venetoclax synergistically improve the immune function of CD8+ T cells.

From: Targeted activation of GPER enhances the efficacy of venetoclax by boosting leukemic pyroptosis and CD8+ T cell immune function in acute myeloid leukemia

Fig. 4: G-1 and venetoclax synergistically improve the immune function of CD8+ T cells.

CD8+ T cells pre-labeled with CFSE were incubated with CM from the OCI-AML2 cells or primary blasts treated with G-1 (1 μM) and VEN (OCI-AML2; 0.02 μM, AML#11; 0.2 μM), alone or in combination for 24 h. A, B ELISA assay of IL-1β and IL-18 levels in supernatant from cell cultures. C, D FCM analysis of CD8+ T cell proliferation. E, F ELISA assay of IL-2 and IFN-γ level in supernatants from cell cultures. The data are expressed as the mean ± SD (n = 3). **p < 0.01, ***p < 0.001.

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