Fig. 5: TPM4 is a downstream gene of SFTA1P and PTBP1 in cervical cancer cells. | Cell Death & Disease

Fig. 5: TPM4 is a downstream gene of SFTA1P and PTBP1 in cervical cancer cells.

From: LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation

Fig. 5

A Heatmap of differentially expressed genes upon knockdown of SFTA1P in C33A and CaSki and knockdown of PTBP1 in SiHa cells, revealed by RNA-seq. B Venn diagrams of differentially expressed genes (DEGs) identified by SFTA1P RNA-seq and PTBP1 RNA-seq (upper) and intersecting DEGs after knockdown of SFTA1P and PTBP1 (lower). C Eight key candidate downstream genes were selected based on our RNA-seq data and literature review, and subsequently evaluated by RT-PCR in CaSki and C-4 I cells transfected with SFTA1P siRNA. D Western blot analysis of TPM4 in CaSki and C-4 I cells with SFTA1P knockdown. E Eight key candidate downstream genes were evaluated by RT-PCR in CaSki and C-4 I cells transfected with PTBP1 siRNA. F Western blot analysis of TPM4 in cervical cancer cells with PTBP1 knockdown. Data are shown as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001.

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