Fig. 6: Schematic model. | Cell Death & Disease

Fig. 6: Schematic model.

From: Role of reactive oxygen species in regulating 27-hydroxycholesterol-induced apoptosis of hematopoietic progenitor cells and myeloid cell lines

Fig. 6: Schematic model.

27HC is the most effective oxysterol in the circulatory system and hematological malignancies. 27HC increases the ROS response and induces apoptosis through the ER stress response pathway. Pharmacological inhibition of CYP7B1 (expected to have an elevation of 27HC) would potentially have fewer long-term hematological side effects, particularly when used in combination with chemotherapy or radiation for the treatment of leukemia patients.

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