Fig. 2: SOCS5 positively regulates the protein expression of HIF-1α in HCC. | Cell Death & Disease

Fig. 2: SOCS5 positively regulates the protein expression of HIF-1α in HCC.

From: SOCS5 knockdown suppresses metastasis of hepatocellular carcinoma by ameliorating HIF-1α-dependent mitochondrial damage

Fig. 2

A Western blot analysis of HIF-1α protein expression in HCC cells after upregulation and downregulation of SOCS5. B Schematic of lung metastases model. C Representative images of lung tissues from nude mice. D The number of metastatic nodules in the lungs. E Immunohistochemical staining of SOCS5 and HIF-1α protein expression in the lungs. F Photographs of tumors after inoculation of stably transfected HCCLM3 cells into nude mice. G The tumor volume of shSOCS5-treated HCCLM3 cells in nude mice. H Mean tumor volume measured by caliper on the indicated weeks. I Immunohistochemical staining of SOCS5 and HIF-1α protein expression in Subcutaneous tumors. **P < 0.01, ***P < 0.001, ****P < 0.0001.

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