Fig. 5: The yeast Atg14 gene codes for one protein, whereas the human ATG14 gene encodes two protein isoforms.
From: SETD2 transcriptional control of ATG14L/S isoforms regulates autophagosome–lysosome fusion
Genome database searches revealed that whereas the yeast Atg14 gene codes for one protein (344 amino acids, aa; UniProt entry: P38270), the human ATG14 gene encodes two isoforms: a long (492 aa) and a short (379 aa) splice isoform, named ATG14L and ATG14S (UniProt entries: Q6ZNE5 and Q6ZNE5-2, respectively). a Schematic illustration of yeast Atg14, human ATG14L and ATG14S proteins with indication of a conserved cysteine repeats domain in the N terminus of yeast Atg14 and human ATG14L involved in ATG14 homo-oligomerization. b Amino acid sequences for yeast Atg14, human ATG14L and ATG14S, with indication of the missing sequence in ATG14S as compared to ATG14L, and location of the cysteine repeats domain in yeast Atg14 and human ATG14L. c Illustration of the structure of the exons and introns present in the ATG14L and ATG14S isoforms based on data extracted from the Ensembl genome browser for the human ATG14 gene.
