Table 2 Ferroptosis inducers (FINs).

From: Ferroptosis: a double-edged sword mediating immune tolerance of cancer

Class

Class characteristics

Compounds example

Suitable for in vivo use

i

GSH depleting compounds [178, 238]

Erastin, PE, IKE, other erastin analogs, sulfasalazine, sorafenib, glutamate [242, 243]

PE, IKE, sorafenib

ii

GPX4 inhibitors [13]

RSL3, ML162, DPI compounds 7,10,12,13,17,18,1

No [244]

iii

Depletion of GPX4 protein and CoQ10 [239]

FIN56, CIN56

Not evaluated yet

iv

Iron oxidation and indirect GPX4 inactivation [240, 241]

FINO2

Not evaluated yet

  1. CIL56 caspase-independent lethal 56, CoQ10 coenzyme Q10, DPI diverse pharmacological inhibitor, FIN56 ferroptosis inducer 56, FINO2 ferroptosis inducer endoperoxide, IKE imidazole ketone erastin, ML162 Molecular Libraries 162, PE piperazine erastin, RSL3 RAS-selective lethal 3.
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