Fig. 1: Tubular β-catenin protects against acute kidney injury after IRI. | Cell Death & Disease

Fig. 1: Tubular β-catenin protects against acute kidney injury after IRI.

From: Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury

Fig. 1: Tubular β-catenin protects against acute kidney injury after IRI.The alternative text for this image may have been generated using AI.

A Experimental design of IRI-induced AKI. B BUN levels and sCr levels in TubCat mice after IRI. *p < 0.05; n =5 in each group. C BUN levels and sCr levels in TubCatKO mice after IRI. BUN, blood urea nitrogen; sCr, serum creatinine; *p < 0.05; n = 5 in each group. D, E Representative micrographs of PAS staining and NGAL immunohistochemical staining at 24 h after IRI in TubCat mice (D) or TubCatKO mice (E), and their quantitative data on histologic injury presented as percentage of intact, moderately, and severely damaged tubules, respectively, after IRI. Dilated or necrotic tubules are indicated by yellow or red arrows; tubular cast formation is marked with yellow asterisks; yellow arrows denote NGAL-positive areas. *p < 0.05 vs. CTL-sham or KO CTL-sham; #p < 0.05 vs. CTL-IRI or KO CTL-IRI; n = 5 in each group. F Double-immunohistochemical staining of NGAL (blue, as indicated by yellow arrows) and β-catenin (red, green arrows) in TubCat-IRI mice or TubCatKO-IRI mice. Scale bar = 100 μm. G Quantitative data on tubular injury presented as percentage NGAL-positive area per HPF in TubCat-IRI mice or TubCatKO-IRI mice, respectively. *p < 0.05; n = 3 in sham groups and n = 5 in IRI groups.

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