Fig. 3: β-catenin reduces kidney cell death in IRI-induced AKI via AKT/p53 signaling. | Cell Death & Disease

Fig. 3: β-catenin reduces kidney cell death in IRI-induced AKI via AKT/p53 signaling.

From: Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury

Fig. 3: β-catenin reduces kidney cell death in IRI-induced AKI via AKT/p53 signaling.

A, B Apoptotic cell death: Representative TUNEL staining and quantification of apoptotic cells per HPF in kidney cortex from TubCat-IRI mice (A) and TubCatKO-IRI mice (B). Red arrows, apoptotic cells; Scale bar = 100 μm. HPF high-power field. *p < 0.05; n = 5 in each group. C, D Necroptotic cell death expressed as protein expression of phosphorylated necroptotic executive proteins, MLKL and RIP3 (p-MLKL and p-RIP3) by Western blots of kidney cortical lysates and quantitative analyses in TubCat-IRI mice (C) and TubCatKO-IRI mice (D). *p < 0.05; n = 5 in each group. E, F Representative Western blots of p-AKT and p-p53 and their quantification in TubCat-IRI mice (E) and in TubCatKO-IRI mice (F). *p < 0.05; n = 5 in each group.

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