Fig. 8: PRDM15 promotes radioresistance and poor prognosis in clinical patients. | Cell Death & Disease

Fig. 8: PRDM15 promotes radioresistance and poor prognosis in clinical patients.

From: PRDM15 interacts with DNA-PK-Ku complex to promote radioresistance in rectal cancer by facilitating DNA damage repair

Fig. 8

A The expression of PRDM15 in colon adenocarcinoma (COAD) (n = 41 for normal tissue, n = 286 for colorectal adenocarcinoma tissue, p < 0.05) in TCGA datasets. B Effect of PRDM15 expression level on colorectal adenocarcinoma patients survival. (n = 69 for high expression, n = 210 for low/medium-expression). C Tissue microarray results of PRDM15 expression in clinical rectal cancer. TRG: tumor regression grade. TRG = 0 indicates complete tumor regression; TRG = 3 indicates the worst tumor regression. D Immunohistochemical staining H score of PRDM15 in rectal cancer tissues. Cancer tissues from TRG3 group was considerably higher than that from TRG0-2 group. Values are given as mean ± SD, two tailed Student’s t test. **P < 0.01. E Kaplan–Meier survival analysis of clinical patients from the microarray. (F) Schematic diagram of how the PRDM15 regulates NHEJ repair and radiosensitivity.

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