Fig. 1: MYBPC3-R495Q+/− pigs developed severe myocardial fibrosis, concomitant with reduced MYBPC3 gene expression and elevated lactic acid concentrations.
From: MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis
A–C The transcript (A) and protein (B, C) expression levels of MYBPC3, TGF-β1, COL1A1, and α-SMA in MYBPC3-R495Q+/− pigs and the age-matched wild-type pigs. ***P < 0.001. D–F Measurements of serum cTNT (D), PCIP (E), and lactic acid (F) in WT and MYBPC3-R495Q+/− pigs. ***P < 0.001; ****P < 0.0001. G, H Masson trichrome staining and quantification of cardiac fibrosis in WT and MYBPC3-R495Q+/− pigs. ***P < 0.001. N = 3 per genotype.
