Fig. 7: MYBPC3 deficiency up-regulated NF-κB/TGF-β1/HIF-1α/aerobic glycolysis signaling cascade in cardiac fibroblasts, contributing to HCM myocardial fibrosis.
From: MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis
MYBPC3 deficiency activated NF-κB signal pathway, which increased TGF-β1, HIF-1α, and aerobic glycolysis signal, leading to premature myocardial fibrosis in HCM.
