Fig. 5: ONX-0914 treatment affects angiogenesis in dsyferlinopathic mice. | Cell Death & Disease

Fig. 5: ONX-0914 treatment affects angiogenesis in dsyferlinopathic mice.

From: Inhibition of the immunoproteasome modulates innate immunity to ameliorate muscle pathology of dysferlin-deficient BlAJ mice

Fig. 5

Representative images and quantification of αSMA (in green), isolectin (in red) and CD31 (in magenta) staining of psoas muscles from 6 m BlAJ, 12 m BlAJ and BlAJ+ONX, 12 m C57Bl. Nuclei were stained in DAPI (blue) (scale bar: 200 μm) (A). Psoas of 6 m BlAJ, 12 m BlAJ and BlAJ+ONX, 12 m C57Bl mice stained with αSMA (in green) and NG2 (in red) with nuclei stained in DAPI (blu) (scale bar: 25 μm) and their quantification (B). Psoas of 6 m BlAJ, 12 m BlAJ and BlAJ+ONX, 12 m C57Bl mice stained with αSMA (in green), PDGFRβ+ (in red) and CD31 (in magenta) with nuclei stained in DAPI (blu) (scale bar: 50 and 25 μm) and their quantification (C). Data are presented as mean ± SD of n = 3 independent experiments with n = 3–6 animals/group. One-way ANOVA and non-parametric test followed by Kruskal–Wallis test: *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.

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