Fig. 1: Upregulation of miR-197-3p in LUAD tissues and exosomes positively correlates with metastasis and angiogenesis.

A The miR-197-3p level in normal and LUAD tissues was detected by qRT-PCR. B Kaplan–Meier survival analysis of LUAD patients. C The miR-197-3p level in primary and metastatic LUAD tissues was detected by qRT-PCR. D CD31 expression in primary and metastatic LUAD tissues was assessed by IHC. E Pearson correlation analysis between miR-197-3p and CD31 expression. F The exosomal miR-197-3p level from serum of healthy donor and LUAD patients was detected by qRT-PCR. G The exosomal miR-197-3p level from serum of primary and metastatic LUAD patients was detected by qRT-PCR. Data were representative images in D. *P < 0.05, **P < 0.01, ***P < 0.001.