Fig. 7: Gpr68 inhibition prevents aneurysm formation induced by AngII administration in Tsc2MKOApoE–/– mice.
From: Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice
Tsc2MKOApoE–/– mice were treated with shRNA-Gpr68 or negative control before AngII pump implantation. At 28 days after the osmotic pumps implantation, mice were sacrificed, and their aortas were obtained. A Representative images of aortic specimens from shRNA-Gpr68 or negative control treated mice. B Incidence of AAA and TAA in shRNA-Gpr68 or negative control treated mice (n = 15). C Comparison of maximal diameters in the ascending thoracic (Asc), descending thoracic (Desc), and suprarenal abdominal (Abd) aortic segments measured with vernier caliper (n = 10). D Representative hematoxylin and eosin (H&E), Verhoeff-van Gieson (VVG), and Masson staining of the abdominal aortic sections. Quantifcation of elastin breaks per section in aortic cross sections (n = 8). Quantitative analysis of Masson staining signals (n = 5). *P < 0.05, vs. mice treated with negative control.
