Table 1 EC50 values (μM) of different cancer cell lines of mitoTRAM-34 and rev-mitoTRAM.

From: Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo

Cell line

mitoTRAM

rev-mitoTRAM

B16F10

1.665 ± 0.2086

7.912 ± 0.5313

MDA-MB-231

1.317 ± 0.07186

4.964 ± 0.2451

COLO-357

1.532 ± 0.2004

9.195 ± 1.075

MiaPACA-2

2.498 ± 0.07353

9.06 ± 1.316

PANC-1

3.03 ± 0.2834

11.61 ± 0.8049

PAN-02

2.255 ± 0.07343

8.768 ± 1.281

  1. Viability was assessed using MTS assays. The concentration at which 50% of the cells were viable was calculated using the curve-fitting function of OriginLab (mean + SEM, N = 3–5).
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