Fig. 3: TNC deficiency reduced kidney fibrosis in animal models. | Cell Death & Disease

Fig. 3: TNC deficiency reduced kidney fibrosis in animal models.

From: Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury

Fig. 3

Deletion of TNC (TNC−/−) significantly attenuated the induction of collagen I assessed by IF following UUO by approximate 30% at day 7 and 10 compared with their wild-type littermates (A, n = 4 for each time point, two-way ANOVA p < 0.05). Consistently, the expression of fibrosis markers, such as collagen Iα, fibronectin and plasminogen activator inhibitor-1 (PAI-1), were significantly lower in TNC−/− mice at UUO day 7 and 10 (B, n = 4 for each time point, two-way ANOVA, p < 0.05). Western blot showed that the proteins of collagen Iα and α-SMA were also significantly reduced in TNC−/− mice at UUO day 7 (C, n = 7, p < 0.05).

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