Fig. 3: BRD4 occupancy at the MGMT promoter region is reduced upon JQ1 treatment. | Cell Death & Disease

Fig. 3: BRD4 occupancy at the MGMT promoter region is reduced upon JQ1 treatment.

From: BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression

Fig. 3: BRD4 occupancy at the MGMT promoter region is reduced upon JQ1 treatment.The alternative text for this image may have been generated using AI.

T98G cells were treated for 2 h with or without [1 µM] JQ1. ChIP-qPCR for BRD4 and Pol II occupancy in the promoter region of MGMT interrogated at both F2 and F3 regions are represented as enrichment (%input). The experiment includes seven independent experiments. P-values were determined by two-tailed ratio paired t-test including correction for variance heterogeneity. *(p < 0.05), ****(p < P ≤ 0.0001).

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