Fig. 1: Cytotoxicity and oxidative stress induced by SeC in Nrf2-addicted and non–Nrf2-addicted cells. | Cell Death & Disease

Fig. 1: Cytotoxicity and oxidative stress induced by SeC in Nrf2-addicted and non–Nrf2-addicted cells.

From: Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis

Fig. 1

A Comparison of Nrf2-regulated protein levels among WiDr and C2BBe1 cells and MSCs. GAPDH was used as loading control (n = 3). The values were presented as average ± SD from three independent repeats. B Cytotoxicity of SeC in WiDr and C2BBe1 cells and MSCs after 24 h of treatment (n = 8). (* and +P < 0.05, ** and ++P < 0.01, *** and +++P < 0.001, compared with same concentration of SeC in WiDr cells). C ROS levels after SeC treatment in WiDr and C2BBe1 cells and MSCs. D Time course of ROS production in WiDr cells after SeC treatment (n = 8). All quantified results of cytotoxicity and ROS were express as mean ± SD from eight independent repeats. (* and +P < 0.05, ** and ++P < 0.01, *** and +++P < 0.001, n = 8, compared with the solvent control group). Significance was determined by an unpaired t test.

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