Fig. 6: Four-gene prognostic signature and its relationship with overall survival in the TCGA-LGG dataset. | Cell Death & Disease

Fig. 6: Four-gene prognostic signature and its relationship with overall survival in the TCGA-LGG dataset.

From: DC vaccines loaded with glioma cells killed by photodynamic therapy induce Th17 anti-tumor immunity and provide a four-gene signature for glioma prognosis

Fig. 6: Four-gene prognostic signature and its relationship with overall survival in the TCGA-LGG dataset.

A Plot of log2 Fold Change expression of the genes from the four-gene prognostic model. For each gene, values of log2FC are presented for the DEAD/ALIVE patient groups and for the PS-PDT/MTX groups versus the corresponding control groups. The conditional control level is shown with a green dash-dotted line. B The risk score of each LGG patient. The median risk score for categorizing patients into low-risk (blue) or high-risk (red) groups is 1.92. C The time to death of dead patients (black) and time until last follow-up of live patients (orange). D Heatmap of gene expression profiles of the four prognostic genes. E Kaplan–Meier survival analysis of high-risk versus low-risk groups. F Time-dependent receiver operating characteristic curve analysis of the four-gene predictive model. G–I Correlation between the four-gene prognostic signature for TCGA-LGG and the infiltration of immune and cancer cell subtypes: CAFs (G), endothelial cells (H) and macrophages (I).

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