Fig. 1: DYRK1A-overexpressed zebrafish embryo model showed shortened/curved body axis.
From: Embryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome
a Morphogenesis of live control (injection with GFP mRNA) and DYRK1A-overexpressed (injection with DYRK1A mRNA) embryos. The arrowheads indicate the dorsal side of the embryo. b Fusion of eyes caused by DYRK1A overexpression resembled the phenotype of lefty1 mRNA injection. c Germ layer marker expression detected by WISH during gastrulation. Orientation: ntla, sox17, and otx2, dorsal views with an animal pole to the top; others, animal-pole views with dorsal to the right. The numbers indicated in each picture are the number (left) of affected embryos with a phenotype similar to what is shown in the picture and the total number (right) of observed embryos. The same number labeling was used thereafter.
