Fig. 4: Regulation of Wnt and TGF-β signaling rescues embryo development and organizer formation in DYRK1A-overexpressed embryos. | Cell Death & Disease

Fig. 4: Regulation of Wnt and TGF-β signaling rescues embryo development and organizer formation in DYRK1A-overexpressed embryos.

From: Embryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome

Fig. 4

a Injection of TGF-β legend sqt mRNA and treatment of Wnt-β-catenin inhibitor ICG-001 simultaneously rescue the abnormal phenotype of the DYRK1A-overexpressed embryo. b sqt mRNA and ICG-001 also recover the ectopic expression of organizer marker genes gsc and chd in the DYRK1A-overexpressed embryo.

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