Fig. 5: The uncovered molecular mechanism from the zebrafish DS embryo model is conserved in DS patients.
From: Embryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome
a Representative western blot assay and corresponding statistics to detect the phosphorylation sites of β-catenin and Hsp90ab1 in amniocytes. b DYRK1A expression positively correlated with the phosphorylation level of β-catenin Ser552 site in HSCs from DS patients. Arrows show the detected HSCs, arrowheads show the colocalization of two proteins. c DYRK1A expression negatively correlated with the phosphorylation level of the Hsp90ab1 S225 site in HSCs from DS patients. Arrowheads in Area 1 show the colocalization of two proteins, and arrowheads in Area 2 show the detected HSCs.
