Fig. 7: The molecular mechanism underlying USP9X-mediated NRP1 deubiquitination enhances liver fibrosis by triggering HSCs.
From: USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells
NRP1 is stabilized and upregulated by the deubiquitinase USP9X. Increased NRP1 levels promote HSC activation and the secretion of elevated levels of ECM and inflammatory factors through cytokine TGF-β1, VEGF and PDGF-BB.
