Fig. 2: Human α-syn expression in the rats injected with intestine or vagus lysate derived from a PD patient. | Cell Death & Disease

Fig. 2: Human α-syn expression in the rats injected with intestine or vagus lysate derived from a PD patient.

From: Intrastriatal injection of Parkinson’s disease intestine and vagus lysates initiates α-synucleinopathy in rat brain

Fig. 2: Human α-syn expression in the rats injected with intestine or vagus lysate derived from a PD patient.The alternative text for this image may have been generated using AI.

a Immunohistochemistry staining shows human α-syn aggregations in the mucosa and submucosal plexus of intestine (left), Schwann cells, and nodose ganglion (right) of the post-mortem PD patient. (Scale bars, 20 μm; high-magnification, 10 μm). b The extracted intestine lysate contains α-syn aggregates, and the expression level of α-syn increased in a volume-dependent manner. The loading quantity of intestine lysate was 5, 10, and 20 μL, separately. c The human-derived α-syn accumulation in the SN and STR of rats injected with PBS, intestine lysate, or vagus lysate. Scale bars, 20 μm. L ipsilateral left brain, R contralateral right brain, SN substantia nigra, STR striatum.

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