Fig. 8: TPX2 promotes the recruitment of PXR to its downstream gene cyp3a4’s promoter or enhancer region. | Cell Death & Disease

Fig. 8: TPX2 promotes the recruitment of PXR to its downstream gene cyp3a4’s promoter or enhancer region.

From: TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs

Fig. 8

Rifampicin was used as an agonist of PXR, and the microtubule aggregation agent, paclitaxel, and the microtubule depolymerizing agent, vincristine, were used in combination with rifampicin. (A) The time points for this step are shown. Using a ChIP assay to detect the recruitment of PXR (B and C) or RXR in the enhancer (XREM) (B and D) and promoter (PXRE) (C and E) regions of cyp3a4. *P < 0.05.

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