Table 7 Overexpression of TPX2 accelerates and knockdown of TPX2 decelerates the metabolism or clearance of sorafenib in HCC cells and tumor tissues.
Cell lines | Control | TPX2 | siTPX2 | |
|---|---|---|---|---|
t1/2 values (hours) | ||||
MHCC97-L | cultured cells | 18.68 (16.52–22.13) | 11.92 (10.86–13.34) | N.A. |
tumor tissues | 28.32 (21.99–44.21) | 13.49 (11.74–15.96) | N.A. | |
MHCC97-H | cultured cells | 15.55 (13.62–18.87) | N.A. | 36.61 (24.00–131.2) |
tumor tissues | 19.67 (13.4–42.24) | N.A. | 27.49 (20.44–45.80) | |
HepG2 | cultured cells | 18.86 (15.65–26.51) | 13.70 (11.99 to 16.71) | >24 h |
tumor tissues | 29.41 (16.01–37.56) | 18.51 (12.29–24.83) | 42.24 (25.08–137.2) | |
