Fig. 9: Proposed working model for promotional effects of circMBOAT2 on ICC progression. | Cell Death & Disease

Fig. 9: Proposed working model for promotional effects of circMBOAT2 on ICC progression.

From: CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export

Fig. 9

CircMBOAT2 derives from the exons 2–3 of the MBOAT2 gene by backsplicing in the nucleus and exporting to the cytoplasm. CircMBOAT2 stabilized PTBP1 to facilitate FASN mRNA cytoplasmic export, which altered the lipid metabolic profile and regulated redox homeostasis in ICC, thus promoting tumor growth.

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