Fig. 5: Hsa_circ_0021727 promotes ESCC cell proliferation, invasion, and migration via miR-23b-5p. | Cell Death & Disease

Fig. 5: Hsa_circ_0021727 promotes ESCC cell proliferation, invasion, and migration via miR-23b-5p.

From: Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFκB pathway

Fig. 5

A and B Wound healing assays evaluating the cell migration ability of KYSE510 cells and TE-1 cells co-transfected with miR-23b-5p and hsa_circ_0021727 overexpression vectors. C Transwell assays showing that miR-23b-5p and hsa_circ_0021727 jointly affected the invasion ability of KYSE510 and TE-1 cells. D Three-dimensional (3D) spheroid invasion assays showing the effects of hsa_circ_0021727 and miR-23b-5p on the growing antennae of KYSE510 and TE-1 cells. E and F MTT assays demonstrating the proliferation capacity of KYSE510 and TE-1 cells co-transfected with miR-23b-5p and hsa_circ_0021727 overexpression vectors. G Colony formation assays indicating that the cell proliferation capability of KYSE510 and TE-1 cells transfected with miR-23b-5p was reversed when the cells were co-transfected with hsa_circ_0021727 (values are expressed as the means ± SD; *P < 0.05).

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