Fig. 1: The CEMIP expression level is associated with lung metastatic progression in liver cancer. | Cell Death & Disease

Fig. 1: The CEMIP expression level is associated with lung metastatic progression in liver cancer.

From: Inhibition of CEMIP potentiates the effect of sorafenib on metastatic hepatocellular carcinoma by reducing the stiffness of lung metastases

Fig. 1

A Representative immunohistochemistry images illustrating CEMIP expression levels in patients with or without lung metastasis. Scale bars, 50 μm. B CEMIP immunohistochemistry staining scores in primary HCC tissues obtained from patients with or without lung metastasis. The CEMIP expression level was significantly higher in the pulmonary metastatic group than in the non-metastatic group (P < 0.05). C Kaplan–Meier curves depicting the time to first lung metastasis (from diagnosis time) based on whether CEMIP expression levels in the primary tumor were low (green) or high (red). D Volcano plot showing the differentially expressed genes (DEGs) between samples exhibiting high (top 10%) and low (bottom 10%) levels of CEMIP expression in the TCGA cohort. E, F GO and KEGG enrichment analyses of significant DEGs (Log2|fold change | >2 and P < 0.001). G Scatter plots depicting the Spearman correlations for CEMIP expression and stromal score. H Gene set enrichment analysis (GSEA) plot showing the enrichment of tumor hallmarks in tumors exhibiting high levels of CEMIP expression (top 10%), in comparison to that in tumors exhibiting low levels of CEMIP expression (bottom 10%).

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