Fig. 5: Eva1a deletion reduces HSPCs apoptosis during hematopoietic regeneration. | Cell Death & Disease

Fig. 5: Eva1a deletion reduces HSPCs apoptosis during hematopoietic regeneration.

From: EVA1A regulates hematopoietic stem cell regeneration via ER-mitochondria mediated apoptosis

Fig. 5: Eva1a deletion reduces HSPCs apoptosis during hematopoietic regeneration.The alternative text for this image may have been generated using AI.

A, B Representative FACS plots (left) and the percentage (right) of Annexin V positive LSK (Lin−cKit+Sca1+) cells (A) and SLAM-HSC (Lin−Sca1+cKit+CD48−CD150+) cells (B) in WT and Eva1aF/F,Vav-Cre mice after 5FU treatment 8 days (n = 5). C Caspase 3/7 activity of the SLAM-HSC cells from WT and Eva1aF/F,Vav-Cre mice after 5FU treatment 8 days (n = 8). D CD45.1 mice after lethal irradiation were transplanted with 1 × 106 BM cells from WT and Eva1aF/F,Vav-Cre mice for 14 days. Representative FACS plots (left) and bar graph (right) depict the percentage of Annexin V positive cells in donor-derived LSK cells (n = 5). E Caspase 3/7 activity of the LSK cells as in (D) (n = 3). Data are presented as mean ± SD, (*p < 0.05, and ***p < 0.001).

Back to article page