Fig. 3: Role of ROS in G4 formation and stability. | Cell Death & Disease

Fig. 3: Role of ROS in G4 formation and stability.

From: Crosstalk between G-quadruplex and ROS

Fig. 3

ROS oxidizes guanine in G4s and blocks the Hoogsteen hydrogen bonds, which disrupts the thermal stability of the G4 structure (a, b). The guanine bases in the surrounding G-rich region can compensate for the missing guanine and stabilize the G4 structure (a). In addition, G4 can also be modified into other structural forms by altering the G4-forming mode (c). Oxidation of the guanine base in the DNA template chain can also form OG. With the help of RNA polymerase, the RNA chain can form R-loop with the original DNA chain and stabilize the G4 structure (d).

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