Fig. 7: ROS regulates oncogene expression depend on G4. | Cell Death & Disease

Fig. 7: ROS regulates oncogene expression depend on G4.

From: Crosstalk between G-quadruplex and ROS

Fig. 7

The ROS in cancer cells oxidizes guanine residues in the oncogene promoter region or mRNA G4s to OG, which activates the G4-mediated DDR pathway and translation. The transcription and translation of oncogenes promot cancer development.

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