Fig. 4: Global identification of genes that are regulated by depletion of RBM4 in senescence.
From: RBM4 regulates cellular senescence via miR1244/SERPINE1 axis
A Venn diagram showing differentially expressed genes overlapping between H1299 and A549 cells with stable knockdown of RBM4 by RNA seq. B Heatmap depicting levels of significantly changed genes in H1299 and A549 cells with stable knockdown of RBM4. C Gene ontology of the overlapped genes in biological processes. D KEGG analysis of overlapped differentially expressed genes. E Functional association network of RBM4-regulated genes in (A) were analyzed using the STRING database, and subgroups are marked according to their functions. F Validation of gene expression changes in RBM4-depleted H1299 cells by real-time RT-qPCR. The meanโยฑโSD of relative fold changes from triplicate experiments were plotted with P values calculated by paired t test.
