Fig. 2: RCC primary and metastatic tumors in scRNA-seq characterization. | Cell Death & Disease

Fig. 2: RCC primary and metastatic tumors in scRNA-seq characterization.

From: Single-cell RNA-seq integrated with multi-omics reveals SERPINE2 as a target for metastasis in advanced renal cell carcinoma

Fig. 2: RCC primary and metastatic tumors in scRNA-seq characterization.

A UMAP plot of non-malignant cells, including T cells, endothelial cells, macrophages, B/Plasma cells, NK cells and fibroblasts identified by maker annotations. B Zoomed in UMAP plot of T cell cluster with CD8+ T cells, CD4+ T cells, and Tregs. Marker gens were listed. C Zoomed in UMAP plot of Fibroblasts with CAFs and Myofib. Marker genes are listed. D UMAP plot of malignant cells shows the Malignant 1–6 subsets. E Bubble plot of top 10 genes expression in Malignant 1–6 subsets; the size of bubble represents the percent expressed of cells; the color represents the mean expression level of each gene in clusters: red means the high expression.

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