Fig. 5: SERPINE2 promotes ccRCC progression, accompanied by EMT. | Cell Death & Disease

Fig. 5: SERPINE2 promotes ccRCC progression, accompanied by EMT.

From: Single-cell RNA-seq integrated with multi-omics reveals SERPINE2 as a target for metastasis in advanced renal cell carcinoma

Fig. 5: SERPINE2 promotes ccRCC progression, accompanied by EMT.The alternative text for this image may have been generated using AI.

A, B Representative images of transwell assay without or with Matrigel shows the migration and invasion abilities among shCtrl, shSERPINE2#1 and shSERPINE2#2 group in Caki-1 cells, relative change compared with shCtrl group. Scale bar = 100 μm. C, D Representative images of transwell assay without or with Matrigel shows the migration and invasion abilities between Vector, OE-SERPINE2 group in 786-O cell, relative change compared with Vector group. Scale bar = 100 μm. E The cell survival rate among shCtrl, shSERPINE2#1 and shSERPINE2#2 group in Caki-1 cells, relative change compared with shCtrl group. F The cell survival rate among Vector, OE-SERPINE2 group in 786-O cell, relative change compared with Vector group. G Whole body bioluminescence (photons/second) following tail vein injection of cells in mice. Differences occurred from day 7 time point (Green line). H The lung tissue of 786-O-OE-SERPINE2 or 786-O-NC-SERPINE2 of mice; the representative lung metastasis site by HE staining. Scale bar = 500 μm; Scale bar = 50 μm. The IHC results of CA9 and SERPINE2; Scale bar = 50 μm; Scale bar = 20 μm. EMT epithelial-mesenchymal transition.

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