Fig. 1: iASPP Deficiency Attenuates CD4+ T Cell Activation and Potentiates Treg Function.
From: Regulation of immunological tolerance by the p53-inhibitor iASPP
A Flow cytometry dot plots (left) and quantification (right) of CD4+ T cell division 72 h after anti-CD3 stimulation analyzed by CFSE dilution. B Flow cytometric quantification of PD-1 expression in CD4+ T cells in (A). MFI median fluorescent intensity. C Flow cytometry contour plots of live-dead stain of CD4+ T cells 72 h after anti-CD3 stimulation. D Flow cytometric quantification of suppressive activity of Treg cells examined by cellular division of responder Tconv cells as measured by CFSE dilution 72 h after co-culture.
