Fig. 4: miRNAs implicated in Hippo pathway dysregulation in gastric cancer.

Oncogenic miRNAs activating YAP/TAZ signaling are often upregulated (in red) in human GC. By contrast, YAP/TAZ inhibiting oncosuppressive miRNAs are reported to be downregulated (in blue) in GC. For each miRNA are indicated the Hippo target/targets, and the functional effects of its/their regulation. The stable circular RNA LARP4 (circLARP4) can reverse the oncogenic role of miR-424-5p, resuming YAP phosphorylation and retention in the cytoplasm, and is often downregulated in GC. Similarly, the long intergenic non-coding RNA linc01133 competes with miR-145-5p to promote YES1-dependent YAP1 nuclear translocation and is upregulated in GC tissues.