Fig. 7: ERK5 inhibition interferes with YAP-dependent migration and gene expression of liver cancer cells in a LATS-independent manner. | Cell Death & Disease

Fig. 7: ERK5 inhibition interferes with YAP-dependent migration and gene expression of liver cancer cells in a LATS-independent manner.

From: Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity

Fig. 7

A Wound healing assay of YAP5SA-expressing HuH7 cells and control cells treated with 10 µM BIX02189 or DMSO for 16 h (T16). The images are representative of two independent experiments performed in duplicate. Cell migration was manually quantified as average distance between the edges of the gap (gap width). B RT-qPCR analysis of the indicated YAP target genes in mutant YAP5SA-overexpressing HuH7 cells (YAP5SA) and in control cells (CTR), treated with 10 µM BIX02189 or DMSO. Data are expressed as relative gene expression and shown as mean ± S.E.M. of three independent experiments. Statistically significant differences are reported (*p < 0.05; **p < 0.01; ***p < 0.001).

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