Fig. 1: The phosphorylation levels of VASP (p-VASP) and cGMP are significantly decreased in epithelial ovarian cancer. | Cell Death & Disease

Fig. 1: The phosphorylation levels of VASP (p-VASP) and cGMP are significantly decreased in epithelial ovarian cancer.

From: Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway

Fig. 1

Represent immunohistochemistry (IHC) images (A) and quantitative data the number of high expression cells (B) on the EGFR, PKG I, and p-VASP (Ser239) in 30 paired adjacent normal and tumor tissues of EOC patient. Error bars represent the means ± SD. Scale bar: 100 μm (left), 50 μm (right). Quantitative data on the expressions (C, D) Western blot analysis the expressions of EGFR, PKG I, p-VASP (Ser239), and VASP in EOC cells (SKOV3 and A2780) and normal ovarian epithelial cells (IOSE80). E ELISA analysis the cGMP concentrations in SKOV3, A2780, and IOSE80 cells. All data are presented as mean ± SD (n = 3 to 5 experiments). Significance was evaluated by Student’s t test in (B) and Ordinary two-way ANOVA analysis followed by Tukey’s multiple comparisons test in (D, E). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 under indicated comparison.

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