Fig. 3: Activation of PKG I attenuated EGF-induced EOC cell migration and invasion in vitro. | Cell Death & Disease

Fig. 3: Activation of PKG I attenuated EGF-induced EOC cell migration and invasion in vitro.

From: Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway

Fig. 3

A, B Representative results of wound healing assays. The bar chart represents the migration distance. Error bars represent the means ± SD of three independent experiments (5 fields/experiment). C, F Representative images Transwell assay was used to detect the effect of PKG I activation on the migration and invasion ability Scale bar, 50 μm. Quantitative data on the migrated and invaded SKOV3 and A2780 cells of Trans-well assay. The data were presented as mean ± SD (n = 3). The bar chart represents the migration and invasion cell numbers. Error bars represent the means ± SD of three independent experiments (5 fields/experiment). Significance was evaluated Ordinary two-way ANOVA analysis followed by Tukey’s multiple comparisons test in (B, D, E). *p < 0.05; **p < 0.01; ***p < 0.001 under indicated comparison.

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