Fig. 6: Activation of PKG I inhibited EGF-induced EGFR/MAPK/ERK pathway. | Cell Death & Disease

Fig. 6: Activation of PKG I inhibited EGF-induced EGFR/MAPK/ERK pathway.

From: Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway

Fig. 6

A The activation of PKG I inhibited the phosphorylation levels of EGFR, c-Raf, MEK1/2, and ERK1/2 in SKOV3 and A2780 cells. Western blot (B) and immunofluorescence imaging (C) analysis the expression of nuclear phosphorylated ERK1/2 in SKOV3 and A2780 cells. Represent images were shown, respectively. Scale bar, 50 μm. D The Co-IP assay revealed that the 8-Br-cGMP-induced EGFR/MAPK/ERK pathway blockade via hampering the EGF-induced EGFR-Grb2-SOS1 binding.

Back to article page