Fig. 6: miR-1275 targets FAAH to coordinate AEA/LPA signalling in GC. | Cell Death & Disease

Fig. 6: miR-1275 targets FAAH to coordinate AEA/LPA signalling in GC.

From: MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer

Fig. 6

A GSEA analysis of FAAH and fatty acid metabolism (data from the gastric adenocarcinoma database in the TCGA). B Heatmap of differential lipid metabolites in negative ion mode after interference with FAAH. C The Volcano plots. D Bar graph of differential lipid metabolites after interference with FAAH. E The content of total PG, PGD2, PGE2, PGF2α, and PGI2 in the cell supernatant was determined by ELISA after FAAH interference and overexpression. F Detection of changes in lipid signal involved in AEA/LPA pathway after interference with FAAH. G Content of total PG and PGE2 in the cell supernatant after treatment with miR-1275 mimic or inhibitor. H Changes of lipid signal in AEA/LPA pathway after co-transfection of miR-1275 and FAAH vectors. I Schematic diagram. *p < 0.05, **p < 0.01, ***p < 0.001. NES normalised enrichment score, FDR false discovery rate.

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