Fig. 5: SOCS3 binds to PTK6 and inhibits PTK6 expression. | Cell Death & Disease

Fig. 5: SOCS3 binds to PTK6 and inhibits PTK6 expression.

From: PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation

Fig. 5: SOCS3 binds to PTK6 and inhibits PTK6 expression.The alternative text for this image may have been generated using AI.

A Network diagram of proteins related to PTK6 from the BioGRID database. B The Venn diagram of IP-MS and BioGRID. C The results of the SDS-PAGE visualized by Coomassie Brilliant Blue staining after immunoprecipitating. D, D’ Coimmunoprecipitation analysis of PTK6 and SOCS3 in UM cells. E, F and E’, F’ Western blotting analysis of SOCS3 and PTK6 in UM cells overexpressing SOCS3. G, H and G’, H’ Western blotting analysis of SOCS3 and PTK6 in UM cells with SOCS3 knockdown. The above data were analyzed using one-way ANOVA with Bonferroni. (D–H: SP6.5 cell; D’–H’: MUM-2B cell; data were presented as the mean ± SD; n = 3; *p < 0.05, **p < 0.01, ***p < 0.001).

Back to article page