Fig. 3: SUM159PT and BT549 NF-YAl-KO clones differential expression and functional analysis.

A Venn diagrams showing the overlap of differentially expressed genes (DEGs) in SUM159PT (Left Panel) and BT549 (Right Panel) YAl-KO clones, compared to the respective wt cell-lines. B Venn diagrams representing the number of shared DEGs between all four YAl-KO clones, compared to wt cell lines. In the Left Panel we included upregulated genes, in the Right Panel downregulated ones. Tables at the bottom detail the genes up- or downregulated in all four YAl-KO clones. C Heatmap depicting enriched MSigDB Hallmark gene sets within the DEGs (vs wt cell lines) of each deleted clone. Upregulated and downregulated gene sets are displayed in yellow and blue, respectively. Intensity of the colour = -log₂(Enrichr Combined Score). Only gene sets with -log₂(CS) > 1 in all four DEG lists were included in the analysis.