Fig. 1: IL-18 is highly expressed in the H1N1 virus-induced mouse model of severe pneumonia. | Cell Death & Disease

Fig. 1: IL-18 is highly expressed in the H1N1 virus-induced mouse model of severe pneumonia.

From: Interleukin-18-primed human umbilical cord-mesenchymal stem cells achieve superior therapeutic efficacy for severe viral pneumonia via enhancing T-cell immunosuppression

Fig. 1

A The body weight change in mice withpneumonia induced by four different viral doses, the EID50 was 1 × 106/ml, 1 × 107/ml, 5 × 107/ml, and 1 × 108/ml, respectively. Only 1 × 108/ml viral doses could induce severe pneumonia, showing body weight loss of more than 20% at day 6 post-infection; n = 5 per group in each time point. B The survival rate of different viral dose groups, and the mice death only occurred in the highest dose group; n = 5 per group at each time point. C The mRNA expression of IL-18 and five important cytokines (TNF-α, IFN-γ, IL-1β, IL-6, and IL-10) in lung tissues were analyzed by qPCR from day 1 to day 14 after H1N1 viral infection; n = 3 per group in each time point. D The protein concentration of different cytokines in BALF was analyzed using an ELISA kit; n = 3 per group at each time point. Data are shown as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001.

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