Fig. 7: LINC00941 functions as a scaffold for ILF2 and YBX1 to promote mRNA stability of SOX2. | Cell Death & Disease

Fig. 7: LINC00941 functions as a scaffold for ILF2 and YBX1 to promote mRNA stability of SOX2.

From: Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma

Fig. 7: LINC00941 functions as a scaffold for ILF2 and YBX1 to promote mRNA stability of SOX2.The alternative text for this image may have been generated using AI.

A, B The stability of SOX2 mRNA was detected by qRT-PCR at the different actinomycin D (5 µg/mL) treatment times in the indicated cells. C, D The interaction of ILF2 or YBX1 with SOX2 mRNA was detected by RIP assay using anti-ILF2 or anti-YBX1 antibodies in the indicated cells. E, F The stability of SOX2 mRNA was detected by qRT-PCR in the indicated cells treated with actinomycin D (5 µg/mL). G–I The expression levels of SOX2 in the indicated cells were detected by qRT-PCR. J The protein levels of SOX2, ILF2, and YBX1 were detected by immunoblot. *P < 0.05 compared with the control cells; #, P < 0.05 compared with ILF2 + siControl (E, G), YBX1 + siControl (F, H), LINC00941 + siControl (I) group, respectively. The experiments are representative of three independent experiments with similar results.

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