Fig. 4: ZBP1/p-MLKL mediated necroptosis existed in BMDMs in BDL livers. | Cell Death & Disease

Fig. 4: ZBP1/p-MLKL mediated necroptosis existed in BMDMs in BDL livers.

From: Necroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p-MLKL axis

Fig. 4

A The schedule of mouse model. B Representative images of p-MLKL (pink) and F4/80 (red) staining in BDL livers. EGFP (green) indicated bone marrow-derived cells. The nuclei were stained with DAPI (blue). Yellow arrows: p-MLKL+F4/80+EGFP+ cells. Scale bar: 15 μm. C Representative images of ZBP1 (pink) and F4/80 (red) staining in BDL livers. EGFP (green) indicated bone marrow-derived cells. The nuclei were stained with DAPI (blue). Yellow arrows: ZBP1+F4/80+EGFP+ cells. Scale bar: 15 μm. D, E Quantitative results of p-MLKL+ (D) and ZBP1+ (E) macrophage number in BDL livers. Data are presented as the mean ± SEM.

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